Warren
S. Warren1, Rosa Tamara Branca2
1Chemistry/CMBI, Duke University,
Durham, NC, United States; 2Chemistry, Duke University, Durham,
NC, United States
A
recent quantum computing paper analytically derived optimal pulse spacings
for a multiple spin echo sequence which differ dramatically from the
conventional, equal pulse spacing of a Carr-Purcell-Meiboom-Gill (CPMG)
sequence. Here we show that this UDD sequence has advantages for MR of
tissue, where diffusion in microstructured environments leads to fluctuating
fields on a range of different timescales.
Both in excised tissue and in a live mouse tumor model, optimal UDD sequences
produce different contrast than do CPMG sequences, with substantial
enhancements in most regions. This provides a new source of endogenous
contrast and enhances sequences which are currently T2-limited.
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