Se Young Chun1, Sanghee Cho1, Tim G. Reese2, Bastien Guerin1, Xuping Zhu1, Jinsong Ouyang1, Ciprian Catana2, Georges El Fakhri1
1Division of Nuclear Medicine & Molecular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States; 2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States
This abstract reports preliminary results of motion corrected MR-PET reconstruction based on B-spline nonrigid image registration and compares it with HARP based motion compensation. With a breathing phantom, we collected MR and PET data simultaneously using BrainPET prototype PET scanner operating in the bore of a 3T TIM Trio scanner. Then we estimate the motion of a phantom using HARP and proposed B-spline based image registration with a novel invertibility penalty. These estimated motions were used in motion compensated iterative PET reconstruction. This preliminary result shows significant improvement of PET images for large motions.