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Abstract #3118

Segmentation of the Rat Hippocampal Mossy Fiber Network from MEMRI Under Inhomogenous B1 Field

Way Cherng Chen1, Kai-Hsiang Chuang1

1Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore

A method of segmenting the rat hippocampal mossy fiber network from MEMRI under inhomogeneous B1 field was introduced. High-pass filtering was used to correct the intensity inhomogeneity, followed by multi-level Otsu thresholding and removal of clusters with 10 or less lpixels to obtain final segmented image. High-pass filtering corrected for intensity inhomogeneity and enhanced the edges of the network making it preferable to N3 correction. Comparison with manual segmentation on 5 data sets yielded a t-value of 0.390>0.05 and a true positive rate of 91.8%.