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Abstract #3145

Construction of a Population Based Diffusion Tensor Image Atlas of the Sprague Dawley Rat Brain

Jelle Veraart1, Bjornar T. Antonsen2, Ines Blockx3, Wim Van Hecke4,5, Yi Jiang6, G. Allen Johnson6, Annemie Van Der Linden3, Trygve B. Leergaard2, Marleen Verhoye3, Jan Sijbers1

1Vision Lab, University of Antwerp, Antwerp, Belgium; 2Center for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; 3Bio Imaging Lab, University of Antwerp, Antwerp, Belgium; 4Department of Radiology, University Hospital Antwerp, Antwerp, Belgium; 5Department of Radiology, University Hospitals of the Catholic University of Leuven, Leuven, Belgium; 6Duke Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States

An anatomically labeled DTI atlas of the adult Sprague Dawley brain is proposed. The atlas is constructed using a population based atlas construction approach to create a template which represents the average anatomy. Further, a bias to a single subject is minimized. During the construction, a non-rigid coregistration technique is used to avoid local misalignment inaccuracies due to intersubject differences. The delineation of brain structures was performed on high resolution ex-vivo scans and the resulting parcellation maps were non-linearly warped into the in-vivo atlas space afterwards. The atlas is perfectly suited for automated ROI analysis and more standardized VBA studies.