Lauren Jean Bains1,2, Josephine H. Naish1,2, David L. Buckley3
1Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, Greater Manchester, United Kingdom; 2University of Manchester Biomedical Imaging Institute, University of Manchester, Manchester, Greater Manchester, United Kingdom; 3Division of Medical Physics, University of Leeds, Leeds, United Kingdom
Quantitative DCE-MRI benefits from the use of individual patient AIFs, however, accurate MRI-based AIF measurements are complicated by partial volume and inflow effects. We tested two methods of AIF correction based on cardiac output, and evaluated their effects on DCE-MRI tracer kinetic parameter estimates by comparing these estimates with DCE-CT, a modality which is unaffected by many of the artefacts that are problematic in DCE-MRI. Our results show that the use of cardiac output to correct DCE-MRI produces parameter estimates which are significantly closer to DCE-CT with reduced variance; the use of such corrections may significantly benefit DCE-MRI analyses.