Does Sub-Regional Analysis of DGEMRIC Allow for Improved Sensitivity?

Wei Li¹, Pottumarthi V. Prasad¹

A recent report suggested sub-regional differences in δR1 following Gd-DTPA2-. We have reanalyzed data from a previous report to compare sub-regional analysis against full thickness analysis. We found higher T1pre- and lower T1Gd in the superficial layer compared to full thickness analysis, resulting in a higher δR1. Our preliminary experience supports the use of superficial layer for routine use which potentially could improve the sensitivity, although the present data only showed a modest increase. It is not clear if there is a need to analyze the deep layer for routine use. Some technical limitations regarding sub-regional analysis are discussed.