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Abstract #3216

Quantitative In-Vivo Assessment of Intervertebral Disc Degeneration in Lumbar Spine Using ADC Measurements

Hon Yu1, Shadfar Bahri1, Lutfi Tugan Muftuler1, Orhan Nalcioglu1, Vance Gardner2

1Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; 2Orthopaedic Education and Research Institute of Southern California, Orange, CA, United States

Measurement of apparent diffusion coefficient (ADC) was investigated as means for in-vivo assessment of the degenerative states in lumbar discs. Pfirrmann grading, currently only-accepted means to assess disc-degeneration in vivo based on morphology, was utilized along with the signal-intensity ratio of disc to cerebral spinal fluid in T2w to classify the discs beyond the 5-level grades afforded by Pfirrmann grading and then to compare with the measured ADC values. The results indicate a strong negative linear correlation between the ADC values and the degenerative grades of discs demonstrating the potential value of ADC as means for in-vivo assessment of disc-degeneration.