Jing Yuan1, Yi-Xiang Wang1, James F. Griffith1
1Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
Quantitative T1rho imaging is a non-invasive MRI technique that has been shown to be sensitive to interactions between motionally restricted water molecules and their surrounding macromolecular environment. It should potentially be a clinical tool in identifying early interverterbral disc (IVD) degeneration. In this study, a spin-lock 3D balanced fast field echo imaging was developed for rapid in vivo IVD T1rho relaxation mapping at 3T. A significant reduction of T1rho relaxation was found to be an indication of early IVD degeneration.