Elina Raja Ahmad1, William Bimson1,
Graham Kemp2
1Magnetic Resonance and Image Analysis
Research C, University of Liverpool, Liverpool, Merseyside, United Kingdom; 2Magnetic
Resonance and Image Analysis Research Centre , University of Liverpool,
Liverpool, Merseyside, United Kingdom
Analysis
of 31P MRS phosphocreatine recovery kinetics provides valuable information about
muscle mitochondrial function in vivo. Correct analysis of the data in terms
of mitochondrial capacity (a function of mitochondrial numbers, function
and substrate/O2 supply) depends on the underlying physiology. We compare the
results of such analysis in quadriceps and calf muscle at 60% and 90% maximum
voluntary contraction force, and with estimates inferred from some published
measurements by invasive methods. Results differ little between the two
muscles, but systematic quantitative differences between methods of assessing
mitochondrial function in vivo remain unexplained.
Keywords