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Abstract #3235

The Effects of Statins on 31P MRS Measured Skeletal Muscle Metabolite Content and Function

Jill M. Slade1, Sean C. Forbes2, George S. Abela3, Robert McClowry1, Ronald A. Meyer1

1Radiology, Michigan State University, East Lansing, MI, United States; 2Physical Therapy, University of Florida; 3Cardiology, Michigan State University

Skeletal muscle content and function may be affected by cholesterol lowering medications (statins). 31P MRS was used to quantify resting and exercise induced changes in muscle metabolism. Muscle aerobic capacity was reduced following 80-mg atorvastatin suggesting comprised skeletal muscle function with statin use.