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Abstract #3245

Effects of Resistance Trainging and β-Hydroxy-β-Methylbutyrate (HMB) on Muscle Fiber CSA and Lean Body Mass in Aged Rats: A DTI and DEXA Study

Ihssan S. Masad1,2, Y-M Park3, S-R Lee3, Jacob M. Wilson3, Paul C. Henning3, Bahram H. Arjmandi3, Samuel Colles Grant1,2, J-S Kim3

1Department of Chemical & Biomedical Engineering, The Florida State University, Tallahassee, FL, United States; 2National High Magnetic field Laboratory, Tallahassee, FL, United States; 3Department of Nutrition, Food & Exercise Sciences, The Florida State University, Tallahassee, FL, United States

SSarcopenia, age-related muscle wasting, has drastic medical and financial impacts on the elderly population. In this study, diffusion tensor imaging (DTI), which is sensitive to muscle architecture, is employed to assess the potential benefits of β-hydroxy-β-methylbutyrate (HMB) and resistance training (RT) in a pre-clinical model of aged rats. DTI was used to evaluate muscle cross sectional area (CSA) while dual energy X-ray absorptiometry was utilized to assess lean body mass (LBM). As well as increasing LBM, results demonstrate that RT caused hypertrophy in aged soleus muscle, as indicated by increased ADC as well as increased second and third eigenvalues.