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Abstract #3306

A New Paradigm for High Sensitivity 19F MRI of Perfluorooctylbromide

Cline Giraudeau1, Julien Flament1, Benjamin Marty1, Fawzi Boumezbeur1, Sbastien Mriaux1, Caroline Robic2, Marc Port2, Nicolas Tsapis3, Elias Fattal3, Eric Giacomini1, Franck Lethimonnier1, Denis Le Bihan1, Julien Valette1

1NeuroSpin, I2BM, Commissariat l'Energie Atomique, Gif-sur-Yvette, France; 2Guerbet, Research Division, Aulnay-sous-Bois, France; 3Universit Paris Sud, UMR CNRS 8612, Facult de Pharmacie, Chtenay-Malabry, France

The NMR properties of perfluorooctylbromide (PFOB) are revisited to derive a high sensitivity MRI strategy. Relevance of the bandwidth of the 180 pulses in a spin echo sequence is evidenced to obviate harmful effects of J-coupling. The T2 of the CF3 resonance of PFOB is measured using a multi spin echo (MSE) sequence and shown to dramatically depend on TE. An optimized MSE imaging sequence is therefore derived and compared with short TE/TR gradient echo and chemical shift imaging sequences. The unparalleled sensitivity yielded by the MSE sequence is promising for future applications, particularly for targeted PFOB nanoparticles.