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Abstract #3309

Metabolite T2 Relaxation Times of Coupled 1H Spin Systems in Human Brain at 7T

Ralf Mekle1,2, Giulio Gambarota3, Lijing Xin1, Rolf Gruetter1,4

1Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Federale de Lausanne, Lausanne, Vaud, Switzerland; 2Department of Radiology, University of Lausanne, Lausanne, Vaud, Switzerland; 3GlaxoSmithKline Clinical Imaging Center, London, United Kingdom; 4Departments of Radiology, Universities of Lausanne and Geneva, Lausanne and Geneva, Vaud and Geneve, Switzerland

The knowledge of the proton T2 relaxation time of coupled metabolites is valuable for improving spectral quantification not only in long TE MRS, but also in a number of MRS editing techniques, which are typically performed at moderate TEs. At the field strength of 7T, the T2 of singlets has already been reported, but not the systematic measurement of the T2s of coupled metabolites. In this study, measurement of the T2 of coupled spin resonances of metabolites in human brain at 7T using the spin echo full intensity acquired localized (SPECIAL) MRS technique is described for the first time.