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Abstract #3325

Modeling of 3-Dimensional MR Spectra of Human Brain: Simultaneous Determination of T1, T2, and Concentrations Based on Combined 2DJ Inversion-Recovery Spectroscopy

Christine Sandra Bolliger1, Daniel Guo Quae Chong1, Johannes Slotboom2, Chris Boesch1, Roland Kreis1

1Department of Clinical Research, University Bern, Bern, Switzerland; 2Departement Radiologie, Neuroradiologie, Nuklearmedizin (DRNN), Inselspital, Bern, Switzerland

In addition to peak areas, full quantitation of in vivo MR spectra requires the measurement of individual metabolite T1s, T2s, and of the macromolecular baseline. Since this is time-consuming, these influences are mostly ignored in a clinical setting, leading to systematic inaccuracies. We propose simultaneous modeling of a combined dataset, called 2DJ-IR, consisting of a 2DJ series and a set of inversion recovery (IR) spectra. Since this allows a determination of relaxation effects and macromolecule baseline in reasonable time, the areas as determined by this method are inherently relaxation-corrected and can be directly interpreted as concentration ratios.