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Abstract #3339

Neurotransmitter Profiling at 3T Using GABA Optimized PRESS Sequence

Antonio Napolitano1, Walter Kockenberger2, Dorothee P. Auer1

1Academic Radiology, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2SPMMRC, University of Nottingham, United Kingdom

The spectroscopic detection of GABA is still challenging due to its low concentration, and the fact that all GABA peaks are overlapped by much stronger metabolite resonances at the field strength accessible for clinical studies. This study aims to simultaneously detect GABA as well as Glu, Gln pools using a standard PRESS localization pulse sequence with optimized timing parameters.