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Abstract #3347

Decreased Energy Metabolism in Patients with Migraine Without Aura: A 31P MRS Study

Harmen Reyngoudt1,2, Benedicte Descamps1,2, Yves De Deene3, Koen Paemeleire4,5, Eric Achten1,2

1Radiology, Ghent University, Ghent, Belgium; 2Ghent Institute for Functional and Metabolic Imaging, Ghent University, Ghent, Belgium; 3Radiotherapy, Ghent University, Ghent, Belgium; 4Basic Medical Sciences, Ghent University, Ghent, Belgium; 5Neurology, Ghent University Hospital, Ghent, Belgium

Most studies emphasized on the quantification of phosphorus metabolites in migraine with aura patients. We re-evaluated the phosphorus metabolism, and its possible basal deficiencies, in a homogeneous migraine without aura (MwoA) patient group between attacks (interictally). We compared 22 MwoA patients with 22 controls. Spectra were acquired in the visual cortex. Absolute quantification was performed by using an external reference. The metabolic shifts found in this study point to a basal metabolic deficiency in MwoA patients