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Abstract #3353

Cerebrospinal Fluid Partial Volume Correction in Quantitative Short TE Magnetic Resonance Spectroscopic Imaging

Ernesto Akio Yoshimoto Ninamango1, Andre Van Der Kouwe2, Fa-Hsuan Lin, 2,3, Lawrence Wald2, Stefan Posse, 1,4

1Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, United States; 2A. A. Martinos Center, Massachusetts General Hospital, Charlestown, MA, United States; 3Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 4Department of Neurology, University of New Mexico, Albuquerque, NM, United States

In this study we investigate the effects of CSF fraction on absolute quantification as a function of spatial resolution for voxel sizes of 0.3, 1.2 and 4.8 cc in data acquired with short TE (15 ms) PEPSI high-speed MRSI on a 3 T scanner equipped with 32 channel head array coil. Bias in pure GM and WM concentration estimates is shown to increase with increasing CSF fraction and voxel size. Increasing spatial resolution is advantageous for clinical studies, reducing sensitivity to partial volume correction when assessing metabolic changes in focal brain lesions and in normal appearing WM and GM.