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Abstract #3359

Metabolic Profile of Pericardial Fluid of Congenital and Acquired Heart Disease Patients and Their Comparison with Serum Using 1H NMR Spectroscopy

Pratima Tripathi1, Nirmal Gupta2, Raja Roy1, C.L. Khetrapal1

1CBMR, Centre of Biomedical Magnetic Resonance, Lucknow, Uttar Pradesh, India; 2Department of Cardiovascular and Thoracic Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

The study focuses on first application of 1H-NMR spectroscopy to human PCF obtained from patients undergoing open-heart surgeries, aiming at identifying metabolites under normal conditions. Total 107 patients were included of which 62 were adults and 45 pediatric patients. The differences in the concentrations of metabolites between adult and pediatric patients are discussed. PCF were also compared with the serum of these patients. Concentrations of lipid resonances were lesser in PCF as compared to serum while small molecular weight metabolites were more in PCF. This analysis may provide a baseline for better understanding of pericardial fluid physiology in diseased conditions. < >