Metabolic Profile of Pericardial Fluid of Congenital and Acquired Heart Disease Patients and Their Comparison with Serum Using 1H NMR Spectroscopy

Pratima Tripathi¹, Nirmal Gupta², Raja Roy¹, C.L. Khetrapal¹

The study focuses on first application of 1H-NMR spectroscopy to human PCF obtained from patients undergoing open-heart surgeries, aiming at identifying metabolites under normal conditions. Total 107 patients were included of which 62 were adults and 45 pediatric patients. The differences in the concentrations of metabolites between adult and pediatric patients are discussed. PCF were also compared with the serum of these patients. Concentrations of lipid resonances were lesser in PCF as compared to serum while small molecular weight metabolites were more in PCF. This analysis may provide a baseline for better understanding of pericardial fluid physiology in diseased conditions. ^{< >}