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Abstract #3364

NMR Spectroscopy Based Evaluation of Urine for Identification of Changes in Functional Metabolites on Exposure to Thallium-201 in Mice

Ritu Tyagi1, Poonam Rana1, Priyanka Saxsena2, M Memita Devi1, Sonia Gandhi1, Sunil Pal3, Subash Khushu1

1NMR Research Centre, INMAS, Delhi, India; 2Department of Nuclear Medicine, INMAS, Delhi, India; 3Division and Cyclotron & Radiopharmaceutical Sciences, INMAS, Delhi, India

Thallium-201 (Tl-201) is routinely used in nuclear medicine scans. Physiologically, it acts as a potassium analog and gets accumulated in the cells leading to some alterations at metabolite levels. Present study was proposed to look upon the changes at metabolite levels in urine samples obtained from Tl-201 treated mice. Urine samples were collected from mice at 3 and 24 hrs post injection of Tl-201.The 1H NMR spectral analysis of urine presented many altered metabolites suggesting a change in energy, amino acid metabolism and gut flora. However, changes observed after Tl-201 injection are functional reversible physiological changes.