Ritu
Tyagi1, Poonam Rana1, Priyanka Saxsena2, M
Memita Devi1, Sonia Gandhi1, Sunil Pal3,
Subash Khushu1
1NMR
Research Centre, INMAS, Delhi, India; 2Department of Nuclear
Medicine, INMAS, Delhi, India; 3Division and Cyclotron &
Radiopharmaceutical Sciences, INMAS, Delhi, India
Thallium-201
(Tl-201) is routinely used in nuclear medicine scans. Physiologically, it
acts as a potassium analog and gets accumulated in the cells leading to some
alterations at metabolite levels. Present study was proposed to look upon the
changes at metabolite levels in urine samples obtained from Tl-201 treated
mice. Urine samples were collected from mice at 3 and 24 hrs post injection
of Tl-201.The 1H NMR spectral analysis of urine presented many altered
metabolites suggesting a change in energy, amino acid metabolism and gut
flora. However, changes observed after Tl-201 injection are functional reversible
physiological changes.