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Abstract #3395

Impact of B1-Inhomogeneities on the Quantification of Ktrans and Ve

Robert Merwa1, Thorsten Feiweier2, Franz Ebner3, Gernot Reishofer3, Karin Kapp4, Rudolf Stollberger5

1Medical Engineering, FH O - Upper Austria University of Applied Sciences, Linz, Austria; 2Healthcare, Siemens AG, Germany; 3Department of Radiology, Medical University of Graz, Graz, Austria; 4Department of Radiation Therapy, Medical University of Graz, Graz, Austria; 5Institute of Medical Engineering, Graz University of Technology, Graz, Austria

The determination of kinetic parameters depends strongly on the inhomogenities of the RF-field. Due to the local magnitude of these inhomogenities the values for the AIF and tissue concentrations are widespread which lead to an overestimation or underestimation of Ktrans and Ve. An essential improvement can be achieved if the dynamic data are corrected accordingly. The absolute difference of Ktrans and Ve obtained with the AIF in two comparable arteries can be improved by a factor up to 33 when using the correction procedure. Also the statistical evaluation of the data shows an improvement if B1 inhomogeneities are corrected.