Meeting Banner
Abstract #3406

Feasibility Study to Measure Changes in Intracranial Pressure Using Magnetic Resonance Poroelastography

Adam J. Pattison1, Phillip R. Perrinez1, Matthew DJ McGarry1, John B. Weaver, 12, Keith D. Paulsen1,3

1Thayer School of Engineering, Dartmouth College, Hanover, NH, United States; 2Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH; 3Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States

Small changes in intracranial pressure (ICP) have large effects on neurological function. Having the ability to measure ICP noninvasively could lead to a much more reliable and efficient method to diagnosing diseases like hydrocephalus, where an increase in ICP and ventricle size can be misconstrued with other ex vacuo changes like periventricular leukomalacia or cerebral atrophy. Magnetic resonance poroelastography (MRPE) is a recent idea in which both a shear modulus and pore-pressure estimate are attainable. A feasibility study was done on tofu, which has been widely used to model brain tissue, in which different external pressures were applied in an enclosed container. Reconstructed values show an increase in average pressure as well as a lack of difference in shear modulus. This is an important indicator for future studies of hydrocephalus and other neurological diseases.