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Abstract #3412

A Theoretical Direct Neuronal Detection Study to Estimate Percentage Local Field Perturbations

Syed Muhammad Anwar1, Greg Cook1, Martyn Paley2

1Electronic and Electrical Engineering, University of Sheffield, Sheffield, United Kingdom; 2Academic Radiology, University of Sheffield, Sheffield, United Kingdom

Direct neuronal detection (DND) of nerve impulses using MR techniques to image brain activity is currently under study as an alternative to BOLD based functional MRI. This work theoretically estimates the percentage local signal perturbations caused by the weak transient neuronal fields, and the effect of various axonal firing delays on these perturbations is also studied. The modelling suggests that detection of neuronal fields should be within the capability of current MR technology, and that better post processing may be required for more reliable and reproducible results.