Oliver Hinds1,
Aaron Hess2, M. Dylan Tisdall3, Hans Breiter3,
Andr van der Kouwe3
1A. A. Martinos Imaging Center at the
McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA,
United States; 2Human Biology, University of Cape Town, Cape Town,
South Africa; 3A. A. Martinos Center for Biomedical Imaging,
Department of Radiology, MGH, Harvard Medical School, Charlestown, MA, United
States
We
performed a direct comparison between BOLD signal measured using single-voxel
functional spectroscopy (FS) and EPI. A pulse sequence that performed both
acquisition methods at each TR was developed and implemented. The FS portion
of the sequence was modeled after a PRESS sequence without water suppression.
An FS VOI and an EPI slice were positioned to sample the same brain region
under visual stimulation. We found that FS gave statistically significantly
higher BOLD estimates than EPI, although by a modest amount.