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Abstract #3444

Increasing FMRI Specificity Using Asymmetric Spin Echo (ASE) Spiral: an ROC-Based Analysis

Kimberly Brewer1,2, Lindsay Cherpak1,2, Tynan Stevens1,2, Ryan D'Arcy1,3, Chris Bowen1,4, Steven Beyea1,4

1Institute for Biodiagnostics (Atlantic), National Research Council of Canada, Halifax, Nova Scotia, Canada; 2Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada; 3Psychology and Radiology, Dalhousie University, Halifax, Nova Scotia, Canada; 4Physics and Atmospheric Science, Radiology and Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada

When studying brain function, both the sensitivity and specificity of a technique are essential for improving accuracy. Most fMRI studies use sequences with T2 weighting to maximize BOLD sensitivity, but T2-weighted sequences are more specific to true BOLD activation within parenchymal tissue compared to activation in draining veins. Using the ASE Spiral technique three images with matched T2-weighting, and varying T2-weighting can be acquired in a single excitation. In this work, we analyzed ASE Spiral images obtained during visual checkerboard stimulus using a Receiver-Operator-Characteristic (ROC)-based analysis, to study changes in specificity as a function of varying relaxation weighting.