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Abstract #3447

Investigating Activation Dependence on Cortical Depth and TE Using 2D FLASH

Rosa Maria Sanchez Panchuelo1, Jack Harmer1, Richard Bowtell1, Susan Francis1

1Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, United Kingdom

Here we examine the echo time dependence of the cortical depth-related grey matter GE BOLD signal change in visual cortex using high resolution (0.35x0.35x1.5 mm3) 2D FLASH imaging at 7 T. A linear dependence of the average fractional signal change with echo time was found for all bands defined across the cortex. There was a reduction in δR2* on moving from the pial surface (1.50.1)s-1 to the border with white matter (0.590.05)s-1, and no evidence of increased δR2* in the stria of Gennari. In contrast, the measured R2* showed a clear peak in the stria of Gennari.