High Resolution GRE BOLD FMRI Using Multi-Shot Interleaved Spiral In/Out Acquisition

Youngkyoo Jung¹, Thomas T. Liu¹, Giedrius T. Buracas¹

Blood oxygenation level dependent (BOLD) fMRI has been widely used for mapping brain function noninvasively. High resolution also affords increased BOLD contrast due to reduced partial volume effects and more accurate localization of BOLD activation. However, current standard acquisition methods for human brain BOLD fMRI typically have relatively low spatial or temporal resolution. We developed the multi-shot interleaved spiral in/out acquisition for high resolution BOLD fMRI. We tested this technique using visual and memory tasks. The proposed high resolution fMRI technique shows excellent activation with large spatial coverage.