Joanna Lynn Hutchison1,2, Traci Sandoval1,
G. Andrew J. Hillis1, Ehsan Shokri Kojori1, M. Amanda
E. Colby1, Michael A. Motes1, Mary Jo Maciejewski1,2,
Bart Rypma1,2
1BrainHealth, University of Texas at
Dallas, Dallas, TX, United States; 2Psychiatry, University of
Texas Southwestern Medical Center, Dallas, TX, United States
Using
a standard space brain-template is an efficient way of determining anatomical
ROIs for functional data analyses. Although individually-derived ROIs would
be preferable, such ROIs are time-intensive to acquire. The present analysis
examined whether or not Colin-derived and individually-derived
anatomically-based ROI methods differed significantly from one another in
terms of both the number of voxels and beta values contained within a
Brodmann-area (BA) ROI. Results suggest that utilizing standard-space
normalization/ROI boundary determination can affect the outcome of
statistical analyses in terms of numbers of voxels and beta values. Caution
should be exercised when using standard-space BA ROIs for PFC.
Keywords