Jonathan Rizzo Polimeni1, Bruce Fischl1,2,
Douglas N. Greve1,
1Athinoula A. Martinos Center for
Biomedical Imaging, Department of Radiology, Harvard Medical School,
Massachusetts General Hospital, Charlestown, MA, United States; 2Computer
Science and AI Lab (CSAIL), Massachusetts Institute of Technology, Cambridge,
MA, United States; 3Harvard-MIT Division of Health Sciences and
Technology, Massachusetts Institute of
Technology, Cambridge, MA, United States
In
this study, we demonstrate a laminar-specific BOLD response using resting
state measurements of functional connectivity within visual cortex by
exploiting the known anatomical connectivity pattern between output Layer
II/III in cortical area V1 and input Layer IV in area MT observed by invasive
studies. This laminar correlation signature was absent from cross-hemispheric
laminar correlations measured between left and right V1. These V1-to-MT
laminar-specific resting state correlations demonstrate the ability of
high-resolution rs-fMRI to probe laminar-specific connections and to infer
the directionality of the connectivity, and provide evidence that the BOLD
signal is controlled, to some degree, on the laminar level.
Keywords