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Abstract #3473

Hypercapnic Scaling of Task Induced FMRI BOLD Signals and Its Dependence on Task Design

Sridhar S. Kannurpatti1, Michael Motes2, Bart Rypma2, Bharat B. Biswal1

1Radiology, UMDNJ-New Jersey Medical School, Newark, NJ, United States; 2Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, United States

Blocked and event related stimulus designs are typically used in fMRI studies depending on the importance of detection power or estimation efficiency. The extent of vascular contribution to variability in blocked and event related fMRI-BOLD response is not known. Using hypercapnic scaling, the extent of vascular weighting in the fMRI-BOLD response during blocked and event related design paradigm was investigated. BOLD data from healthy volunteers performing a block design motor paradigm and an event related memory paradigm that needed the performance of a motor task were analyzed from the region of interest (ROI) surrounding the primary and supplementary motor cortices.