Manus Joseph Donahue1,2, Bradley J.
Macintosh2,3, Ediri Sideso4, James Kennedy4,
Peter Jezzard1,2
1Clinical Neurology, Oxford University,
Oxford, United Kingdom; 2Physics Division, FMRIB Centre, Oxford,
United Kingdom; 3Imaging & Brain Sciences, Sunnybrook Health
Sciences Centre, Toronto, Ontario, Canada; 4Nuffield Department of
Clinical Medicine, Oxford University, Oxford, United Kingdom
Inflow
vascular-space-occupancy with dynamic subtraction (iVASO-DS) has been
proposed as a non-invasive approach for measuring arterial cerebral blood
volume (aCBV). Here, we compare iVASO-DS contrast with DSC-measured CBF, CBV
and MTT in patients with stenotic artery disease. We find consistency between
iVASO and DSC-CBV, especially when MTT discrepancies are accounted for.
Finally, in patients with moderate-to-severe stenoses, CBF is generally
symmetric between unaffected and affected hemispheres (R=0.85), yet iVASO
contrast is more asymmetric (R=0.69). This finding is consistent with
autoregulatory vasodilation and indicates that aCBV adjustments may precede
CBF reductions in patients with stenotic artery disease.
Keywords