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Abstract #3485

Arterial Cerebral Blood Volume (ACBV)-Weighted Inflow Vascular-Space-Occupancy (IVASO) Provides Complementary Hemodynamic Information to Dynamic Susceptibility Contrast in Patients with Stenotic Artery Disease.

Manus Joseph Donahue1,2, Bradley J. Macintosh2,3, Ediri Sideso4, James Kennedy4, Peter Jezzard1,2

1Clinical Neurology, Oxford University, Oxford, United Kingdom; 2Physics Division, FMRIB Centre, Oxford, United Kingdom; 3Imaging & Brain Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 4Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom

Inflow vascular-space-occupancy with dynamic subtraction (iVASO-DS) has been proposed as a non-invasive approach for measuring arterial cerebral blood volume (aCBV). Here, we compare iVASO-DS contrast with DSC-measured CBF, CBV and MTT in patients with stenotic artery disease. We find consistency between iVASO and DSC-CBV, especially when MTT discrepancies are accounted for. Finally, in patients with moderate-to-severe stenoses, CBF is generally symmetric between unaffected and affected hemispheres (R=0.85), yet iVASO contrast is more asymmetric (R=0.69). This finding is consistent with autoregulatory vasodilation and indicates that aCBV adjustments may precede CBF reductions in patients with stenotic artery disease.