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Abstract #3497

On the Relationship Between Seed-Voxel and ICA Measures of Functional Connectivity

Suresh Emmanuel Joel1,2, Brian S. Caffo3, Peter CM van Zijl1,2, James J. Pekar1,2

1Radiology, Johns Hopkins University, Baltimore, MD, United States; 2FM Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Biostatistics, Johns Hopkins University, Baltimore, MD, United States

Two methodologies are widely used for evaluating brain functional connectivity from BOLD fMRI data: Correlation with the time series of a specified seed voxel (or small region of interest); and spatial independent component analysis (ICA). While results from seed-voxel and ICA methodologies are generally similar, they can also differ, and we are unaware of a discussion of the relationship between them. The present study is intended to elucidate and illustrate the relationship between seed-voxel and ICA derived measures of FC and to show that FC measures from the two methods are complementary.