Anesthesia Modulated Correlation Between Spontaneous FMRI BOLD and Local Field Potentials in Rat Somatosensory Cortex

Wen-Ju Pan¹, Garth Thompson¹, Matthew Magnuson¹, Waqas Majeed¹, Dieter Jaeger², Shella Keilholz¹

To investigate the relationship between spontaneous fMRI BOLD and neural electrophysiological signal, we developed a combined imaging and recording techniques for the rodent model. By comparing BOLD and local field potential (LFP) in rat somatosensory cortex under different anesthesia states, the studies showed close relationship between the measurements from different modalities and demonstrated that the time lag of the correlation may be modulated by anesthesia types of probe, which provided insights on the neural base of spontaneous BOLD fluctuations.