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Abstract #3539

Functional Networks of the Anesthetized Rat Brain at Rest

R. Matthew Hutchison1,2, Seyed M. Mirsattari3, Craig K. Jones4, Joseph S. Gati1, L. Stan Leung5

1Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; 2Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada; 3Clinical Neurological Sciences, University of Western Ontario; 4F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 5Physiology and Pharmacology, University of Western Ontario

This work is an examination of the spatio-temporal dynamics of low-frequency hemodynamic fluctuations of the anesthetized rat brain. Applying independent component analysis to baseline BOLD fMRI timecourses, synchronous bilateral cortical and subcortical networks were observed including: primary and secondary somatosensory cortices; motor cortices; striate cortices; posterior and anterior cingulate; hippocampi; caudate putamen; and thalamic nuclei. Networks were preserved under two different anesthetic regimes: isoflurane and ketamine/xylazine. This technique has allowed a complete exploration of the resting networks in the rat brain that was not afforded by previously used correlational techniques that have been used for rat imaging.