Peter Herman1,2,
Robert N. S. Sachdev3, Basavaraju G. Sanganahalli1,
Fahmeed Hyder1,4
1Department of Diagnostic Radiology,
Yale University, New Haven, CT, United States; 2Institute of Human
Physiology, Semmelweis University, Budapest, Hungary; 3Department
of Neurobiology, Yale University, New Haven, CT, United States; 4Department
of Biomedical Engineering, Yale University, New Haven, CT, United States
Evoked
responses in functional studies show baseline dependence, we asked if we can
observe baseline differences in power of spontaneous fluctuations of BOLD
signal. We compared spontaneous neural and BOLD signal fluctuations in high
and low energy baseline states of light (domitor) and deep (α-chloralose)
anesthesia. Extracellular electrodes were used to measure local field
potential (LFP) and multi-unit activity (MUA) from middle cortical layers of
rat brain and compared these neural signals with BOLD signal (11.7T). Results
show that the power of spontaneous LFP or MUA activities is correlated with
the magnitude of BOLD signal fluctuations in a baseline-dependent manner.
Keywords