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Abstract #3555

Assessment of Cardiac Remodelling After Myocardial Infarction in Diabetic Mice Using Self-Gated MRI

Kristine Skrdal1, Natale Rolim1, Ole Christian Eidheim2, Marius Widere1, Ulrik Wislff1, Pl Erik Goa3, Marte Thuen1

1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway; 2Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway; 3Department of Medical Imaging, St. Olavs University Hospital, Trondheim, Norway

Type II diabetic patients suffer from higher susceptibility to develop post myocardial infarction (MI) heart failure. By adapting a self-gated FLASH to a murine model of the diabetic heart, we obtained multiple slices of the left ventricle and assessed changes in cardiac physiology post MI. Diabetic MI mice displayed decreased cardiac contractility and increased end-systolic volume, while non-diabetic MI mice presented increased end-diastolic volume with preserved ejection fraction. These data suggest that imaging of murine hearts is achievable using a self-gated FLASH, and the results are accurate enough to detect differences in functional analysis between genotypes and interventions.