Ziheng Zhang1, Donald P. Dione1, Peter B. Brown1, Erik M. Shapiro1, Chengqing Wu2, Robert Todd Constable1, Albert J. Sinusas1, Smita Sampath1
1Yale University School of Medicine, New Haven, CT, United States; 2Yale University School of Public Health, New Haven, CT, United States
A novel MR imaging technique, spatial modulation of magnetization with polarity alternated velocity encoding (SPAMM-PAVE), is presented to investigate the left ventricular early diastolic strain-velocity relationships. This technique provides simultaneous measurements of 1-D myocardial displacement and chamber blood velocity with a high temporal resolution of 14 ms, sensitive to early diastolic events undetectable by current state-of-the-art methods. The reliability of the measurement is demonstrated by an intra-subject study of a normal volunteer. The interplay of regional volumetric changes in the left ventricle in response to filling patterns is investigated through comparing the regional strain and blood inflow velocity curves in 8 normal volunteer studies.