Left Ventricular Dyssynchrony: Effect of Age, Ejection Fraction, Mass and Cardiovascular Disease

Daniela Foell¹, Bernd Jung², Elfriede Schilli³, Felix Staehle², Christoph Bode³, Michael Markl²

MR tissue phase mapping (TPM) was employed to study the relationships of age, heart rate, left ventricular (LV) ejection fraction (EF), and LV-mass with myocardial dyssynchrony among 95 subjects with normal and pathological cardiac function. Compared to age-matched controls significantly (p<0.01) enhanced myocardial dyssynchrony was found in patients with hypertensive heart disease (n=18) and dilated cardiomyopathy (n=12) with most prominent changes if left bundle branch block was present (n=7). Multiple regressions revealed significant relationships of dyssynchrony with LV-EF, LV-mass, and age. As sensitive markers for LV dysfunction, both radial systolic and long-axis diastolic dyssynchrony were superior to systolic long-axis dyssynchrony.