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Abstract #3612

The Patho-Physiological Sensitivity of Cardiac MR Elastography: Preliminary Results.

Thomas Elgeti1, Mark Beling2, Dieter Klatt1, Sebastian Papazoglou1, Sebastian Hirsch1, Kerstin Riek1, Bernd Hamm1, Jrgen Braun3, Ingolf Sack1

1Institut fr Radiologie, Charit Universittsmedizin , Berlin, Germany; 2Klinik und Poliklinik fr Kardiologie, Charit Universittsmedizin , Berlin, Germany; 3Institut fr Medizinische Informatik und Biometrie, Charit Universittsmedizin , Berlin, Germany

MR Elastography (MRE) is capable to directly measure tissue stiffness. This is particularly interesting for cardiac applications, since the cardiac shear modulus changes over the cardiac cycle. It is known, that increasing myocardial stiffness yields decrease of wave amplitudes in MRE. Therefore, left ventricular shear wave amplitudes were measured in 11 healthy volunteers and 11 patients with relaxation abnormalities. It is observed, that shear wave amplitudes are significantly lower in the left ventricle of patients. This result indicates the sensitivity of amplitude-based cardiac MRE to identify increased myocardial stiffness.