Li-Yueh Hsu1, Daniel W. Groves1, Anthony H. Aletras1, Peter Kellman1, Andrew E. Arai1
1National Institutes of Health,
We developed a fully quantitative method to estimate myocardial blood flow (MBF) in first-pass contrast-enhanced perfusion MR images at the pixel level. The results were validated in an animal model and show that the MR perfusion estimates correlated with microspheres over a wide range of absolute MBF. To test feasibility in humans, the method was also applied to clinical perfusion MR images to estimate pixel-wise MBF at rest and during stress.