Wen Li1,2, Wei Li1,2, Chris Flask2,3, Mark Griswold2,3, Xin Yu1,2
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States; 3Department of Radiology, Case Western Reserve University, Cleveland, OH, United States
A modified ECG-triggered saturation recovery Look-Locker (MSRLL) method was developed for quantification of arterial input function via rapid T1 mapping in dynamic contrast enhanced MRI (DCE-MRI) studies. High temporal resolution (< 2 min) was achieved by acquiring only the low spatial frequency lines. High spatial frequency lines acquired before contrast were used to generate composite images with higher spatial resolution. Validation was performed by comparing T1 values measured with SRLL and MSRLL method in both phantom and in vivo mouse heart. The in vivo application of MSRLL in DCE-MRI studies was demonstrated in mouse heart. These results suggest that MSRLL may provide a robust method for rapid T1 mapping of blood and myocardium in cardiac DCE-MRI studies.