Omar El-Sherif1,2, Robert Z. Stodilka1,2, Nathan A. Pack3,4, Edward VR Dibella3,4, James A. White5, Robert Terry Thompson1,2, Frank S. Prato1,2
1Imaging, Lawson Health Research Institute, London, Ontario, Canada; 2Medical Biophysics, University of Western Ontario, London, Ontario, Canada; 3Department of Bioengineering, University of Utah, Salt Lake City, UT, United States; 4Radiology, Utah Center for Advanced Imaging Research, Salt Lake City, UT, United States; 5Cardiology, London Health Sciences Centre, London, Ontario, Canada
We introduce a novel minimally constrained myocardial perfusion analysis technique. The technique has been implemented on dynamic contrast enhanced magnetic resonance images, obtained from 10 patients with hypertrophic cardiomyopathy. Regional myocardial perfusion estimates were directly compared to both the Fermi perfusion model and a 2 compartment perfusion model. The results indicate that there is discrepancy between Fermi and 2 compartment models during stress exams. However our technique correlates well with the Fermi model during both stress and rest exams.