Abstract #3641

Manganese-Enhanced MRI Combined with Delayed Enhancement MRI Detects Injured Border Zone Myocardium in a Pig Ischemia-Reperfusion Model

Rajesh Dash¹, Jaehoon Chung¹, Yuka Matsuura¹, Fumiaki Ikeno¹, Jennifer Lyons¹, Tomohiko Teramoto¹, Alan C.Y. Yeung¹, Michael V. McConnell^1,2, Todd J. Brinton¹, Phillip Harnish³, Phillip C. Yang¹

¹Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA, United States; ²Department of Electrical Engineering, Stanford University , Stanford, CA, United States; ³Eagle Vision Pharmaceutical Corporation, Exton, PA, United States

Manganese-enhanced MRI (MEMRI) detects Mn²⁺ uptake into viable cells, a distinct mechanism from gadolinium delayed enhancement MRI (DE-MRI). We tested whether combined DE-MRI plus MEMRI would delineate peri-infarct border zone injury in a pig ischemia-reperfusion (IR). Pigs were imaged by cardiac MRI 3 weeks post-IR. 3D DE-MRI scar volume correlated with histopathologic scar volume, but MEMRI scar volume was significantly smaller than DE-MRI scar volume. The border zones of DE-MRI scar, which were also positive by MEMRI, showed decreased SNR compared to remote zone MEMRI SNR. Combined MEMRI and DE-MRI may identify injured border zone myocardium in ischemic cardiomyopathy.