Mihaela Pop1, Venkat Ramanan, Yuesong Yang, Nilesh Ghugre, Beiping Qiang, Elliot R. McVeigh2, Alexander J. Dick3, Graham A. Wright
1Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; 2Biomedical Engineering, Johns Hopkins University, United States; 3Cardiology, Sunnybrook Research Institute
Accurate assessment of the scar extent and tissue remodeling during healing is very important. To better understand the scar morphology associated with chronic infarct in a porcine model, we have developed and tested (ex vivo) a 3D pulse sequence based on multi-contrast late enhancement (MCLE) and a non-contrast 3D diffusion-weighted DW sequence, and compare the results against histopathology. We have found that 3D MCLE identifies fine heterogeneity of scar, and compares well the classification of pathology to that from apparent diffusion coeficient maps using DW-MRI.