Christakis
Constantinides1, Nikolas Aristokleous1, Konstantinos
Fokianos2, Jeff Brandenburg3, Dimitrios Perperidis1
1Mechanical and Manufacturing
Engineering, University of Cyprus, Nicosia, Cyprus; 2Mathematics
and Statistics, University of Cyprus, Nicosia, Cyprus; 3Radiology,
Duke University Medical Center, Durham, NC, United States
Quantitative
characterization of ventricular function has become important for the
assessment of cardiac performance in heart disease. As the manipulation of
the mammalian genome becomes routine, it is now possible to generate animal models
to study cardiovascular function and dysfunction. Critical to successful
phenotypic screening of mouse models of the cardiovascular system using MRI
are highly efficient four-dimensional (4D) acquisition protocols, and
reduction of the computational image processing complexity for accurate
quantification. The -goal of this study is the efficient, quantitative
assessment of interstrain cardiac performance in C57BL/6J and DBA/2J mouse
hearts under anesthesia, using MRI.
Keywords