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Abstract #3725

Interstrain Comparisons of Murine Global Cardiac Mechanical Function Using MRI

Christakis Constantinides1, Nikolas Aristokleous1, Konstantinos Fokianos2, Jeff Brandenburg3, Dimitrios Perperidis1

1Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus; 2Mathematics and Statistics, University of Cyprus, Nicosia, Cyprus; 3Radiology, Duke University Medical Center, Durham, NC, United States

Quantitative characterization of ventricular function has become important for the assessment of cardiac performance in heart disease. As the manipulation of the mammalian genome becomes routine, it is now possible to generate animal models to study cardiovascular function and dysfunction. Critical to successful phenotypic screening of mouse models of the cardiovascular system using MRI are highly efficient four-dimensional (4D) acquisition protocols, and reduction of the computational image processing complexity for accurate quantification. The -goal of this study is the efficient, quantitative assessment of interstrain cardiac performance in C57BL/6J and DBA/2J mouse hearts under anesthesia, using MRI.