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Abstract #3741

A DNA-Targeted Gadolinium Chelate to Selectively Enhance Acutely Injured Myocardium

Shuning Huang1, Hushan Yuan2, Howard Chen3, Guangping Dai1, Lee Josephson2, David E. Sosnovik1,3

1Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2Center for Translation Nuclear and Molecular Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 3Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, MA, United States


Delayed enhancement of gadolinium cannot discriminate acute and chronic injury since both produce similar changes in the pharmacokinetics of small gadolinium chelates, such as Gd-DTPA. Here, we demonstrated that the acute myocardial infarction can be distinguished from both subacute and chronic myocardial injury by utilizing a DNA-targeted gadolinium chelate (Gd-TO).

Keywords

myocardial