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Abstract #3752

In Vivo Detection of a PARACEST Agent in Mouse Brain Tumors

Alex Xuexin Li1, Mojmir Suchy2, Chunhui Li1, Claire Poppe1, Joseph Gati1, Susan Meakin1, Robert H.E. Hudson2, Ravi S. Menon1, Robert Bartha1

1Robarts Research Institute, London, ON, Canada; 2The University of Western Ontario

A methodology to detect the on-resonance paramagnetic chemical exchange effects (OPARACHEE) of a PARACEST contrast agent: Tm3+-DOTAM-Glycine (Gly)-Lysine (Lys) in a mouse brain tumor model was developed. The OPARACHEE effect was isolated from the relaxation effects induced by the PARACEST agent using a control image and an OPARACHEE image. Isolated OPARACHEE contrast (1-3%) was observed in all animals. Immediately after contrast agent injection OPARACHEE contrast was observed and maintained at 1~2% in the hour following injection.