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Abstract #3758

"Does Higher R1 Relaxivity Transfer in Improved Vessel Enhancement of the Run-Off Vasculature?" - Evaluation of Macrocylic Gadolinium Chelates for Peripheral MR-Angiography at 3 T by an Inter-Individual Comparison of Gadobutrol Vs Gadoterate Meglumine, Bo

Ulrike I. Attenberger1, Matthias Voth2, Andre Luckscheiter3, Stefan Haneder1, Stefan O. Schoenberg4, Henrik J. Michaely1

1Department of Clinical Radiology and Nuclear Medicine, University Medical Center Manheim, Mannheim, Germany; 2Bayer Schering AG, Berlin, Germany; 3University of Heidelberg, Heidelberg, Germany; 4Department of Clinical Radiology and Nuclear Medicine, University Medical Center Manheim , Mannheim, Germany

Since nephrogenic systemic fibrosis (NSF) has been linked to gadolinium-chelate administration in patients with impaired renal function, contrast agent dose and chelate stability have attracted broad attention. Numerous studies have demonstrated linear compounds to be the least stable, whereas the macrocyclic compounds are the most stable. With the approval of gadobutrol, a double concentrated macrocyclic gadolinium chelate became available, characterized by the highest R1-relaxivity among the macrocyclic gadolinium chelates. The aim of this study was to evaluate the enhancement characteristics of gadobutrol and gadoterate meglumine, both injected at a dose level of 0.07 mmol/kg BW, for peripheral MR-angiography.