Yijing Wu1, Kevin M. Johnson1, Steven R. Kecskemeti1, Charlse A. Mistretta2, Patrick Alan Turski3
1Medical Physics, University of Wisconsin, Madison, Madison, WI, United States; 2Medical Physics and Radiologly, University of Wisconsin, Madison, Madison, WI, United States; 3Radiology, University of Wisconsin, Madison, Madison, WI, United States
Time resolved contrast-enhanced magnetic resonance angiography has been widely used to evaluate vascular hemodynamics. Due to recent concern of the NSF disease, eliminating or reducing Gadolinium-based contrast agent is desirable. HYBRID HYPR decouples the high spatial resolution and SNR, which require relative long scan time, from the high temporal resolution, which demands for fast data acquisitions. It used the HYPR constrained reconstruction to obtain high temporal resolution, high spatial resolution, and high SNR image series. The hypothesis of this work is that the contrast dose can be reduced using the HYBRID HYPR technique: the SNR of the HYPR images is primarily determined by the composite, which is generated using minimal mount of contrast agent (e.g. post contrast phase-contrast images) or can be acquired before contrast injection (e.g. Time-of-Flight images). High temporal and spatial resolution time resolved contrast-enhanced MRA can be obtained by using Low Dose HYBRID HYPR method with contrast dose as low as 1ml.