Abstract #3784

MRI Determined Carotid Artery Flow Velocities and Wall Shear Stress in a Mouse Model of Vulnerable and Stable Atherosclerotic Plaque

Gustav Jacob Strijkers¹, Glenda S. van Bochove¹, Roel Straathof¹, Rob Krams², Klaas Nicolay¹

¹Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; ²Department of Bioengineering, London Imperial College, London, United Kingdom

We report here on the pre-clinical MRI characterization of an apoE-/- mouse model of stable and vulnerable carotid artery atherosclerotic plaques, which were induced by a tapered restriction (cast) around the artery. Specific focus was on the quantification of flow velocities and wall shear stress (WSS), which are considered key players in the development of the plaque phenotype.