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Abstract #3847

Development of a Receive-Only Inductively-Coupled RF Coil System to Enhance 1H NMR Localized Spectroscopy to Monitor an Implantable Bioartificial Construct at 11.1T

Nelly A. Volland1, Thomas H. Mareci2,3, Nicholas E. Simpson4

1Radiology, University of Utah, Salt Lake City, UT, United States; 2Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States; 3McKnight Brain Institute, University of Florida, Gainesville, FL, United States; 4Medicine, University of Florida, Gainesville, FL, United States

Introduction: Uniform excitation and highly sensitive signal detection is necessary for optimal MRS of bioartificial constructs, particularly when determining function. Methods: Receive-only implantable coils were constructed, coated, and integrated with the macroconstruct. This assembly was inductively-coupled to an external coil and tested in vitro in combination with a transmit-only volume coil at 11.1T. Results: Studies showed small overall gains in SNR with this system under loaded conditions over a transmit-receive system, and greater signal uniformity. Conclusion: A receive-only implantable coil system was successfully built and tested. This system will allow for superior quantitative monitoring of implanted bioartificial organs.